Stephanus (Stephan) F. van Eeden

Stephanus (Stephan) F. van Eeden MD, PhD, FRCPC(C)

Professor, Department of Medicine, 
University of British Columbia
The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research
St. Paul's Hospital, Burrard Building,
Room 166 - 1081 Burrard Street, Vancouver, B.C. V6Z 1Y6
Phone: (604) 806-8346 (ext 63142)
Fax: (604) 806-9274
E-mail: svaneeden@mrl.ubc.ca

Dr Stephan van Eeden is an Internist at St Paul's Hospital and Professor with the faculty of Medicine attached to the Division of Internal Medicine & Respirology. He graduated from the University of Stellenbosch, Cape Town, South Africa in 1975, and after four years as a family practitioner resumed his studies in Internal Medicine at the same University. He trained and certified in Pulmonology and Critical Care in 1985 and was promoted to Director of Critical Care, Tygerberg Hospital, University of Stellenbosch in 1989. He did his PhD in the Department of Experimental Medicine, University of British Columbia with DR James C Hogg as his supervisor. He graduated in 1995 and completed his Canadian specialist examination (FRCPC) in 1996. He is currently Director of the COPD Chronic Disease Management Program at PHC.

Research Activities: 
The focus of his research efforts are the mechanisms of lung inflammation, particularly, lung inflammation caused by infection, cigarette smoking and air pollution. This research covers a broad range of clinical conditions such as pneumonia, chronic bronchitis, emphysema and acute respiratory distress syndrome. Current research addresses the response of the bone marrow during acute and chronic lung inflammation. He has shown that white cells released from the bone marrow play a crucial role in the lung inflammation elicited by cigarette smoke and particulate air pollution. This research has lead to the novel hypothesis that white cells released from the bone marrow are responsible for the increase in heart and lung disease and deaths in subjects exposed to high levels of air pollution. This research has given him international recognition as an expert on the bone marrow response during inflammation and the response of the heart and lung to air pollution. It has led to several landmark publications including in 2002 his group was the first to show that air pollution causes the development and progression of atherosclerosis, the underlying disease in vessels responsible for stroke and heart attacks. He recently (2008) showed that pro-inflammatory mediators generated in the lung are responsible for the downstream adverse cardiovascular health effects of exposure to air pollution.

Dr van Eeden spends the majority of his time (~50%) in the James Hogg Research Laboratory & iCAPTURE Center, St Paul's Hospital. His research has resulted in 93 peer-review publications, numerous abstracts and presentations at national and international meetings. He is the recipient of the Martin F Hoffman Award for Excellence in Research and the Department of Medicine Faculty Research award, St Paul's Foundation and CIHR research fellowship. He is also a Career Investigator of the American Lung Association, Senior Scholar of the Michael Smith Foundation for Health Research and the recipient of the Thurlbeck Distinguish Research Award. 
His work has been strongly influenced by long-standing collaborations with many scientists including Drs. James C Hogg, Claire Doerschuk, Blair AM Walker, Scott Simon, Renaud Vincent and George Agnes and the national levels and numerous other scientist on international level as well as interactions with numerous research fellows and students.