Andy Sandford

Andy Sandford, B.Sc. (Hons), PhD

Associate Professor, Respiratory Medicine
University of British Columbia

Dr. Sandford earned his B.Sc. in biological sciences from the University of Leicester, England in 1988 and a Ph.D. studying the genetic basis of allergic diseases such as asthma at the University of Oxford, England in 1993. He continues to research the genetic basis of asthma and has extended his studies to include the genetic basis to chronic obstructive pulmonary disease and the genetic basis of pulmonary disease severity in cystic fibrosis. Dr. Sandford currently holds a Tier 2 Canada Research Chair and a Michael Smith Foundation for Health Research Senior Scholar Award. The focus of Dr. Sandford’s research is investigation of the genetic basis of obstructive lung disease. He is currently studying three large cohorts of individuals. The first cohort was recruited by Drs. Moira Chan-Yeung from UBC and Allan Becker from the University of Manitoba. This cohort contains infants at high risk for developing allergic diseases and is being used to evaluate the importance of genetic risk factors for the development of these diseases. The second cohort was recruited as part of the NHLBI Lung Health Study and contains individuals whose lung function has been followed for five years. Genetic factors that affect the rate of decline of lung function are being investigated in this cohort. This work is a collaboration with Drs. John Connett from the University of Minnesota and Nicholas Anthonisen from the University of Manitoba. The third cohort consists of cystic fibrosis patients and their relatives that are being recruited in a collaborative study with investigators at Toronto’s Hospital for Sick Children. This is a multi-center study to study modifier genes in cystic fibrosis and involves investigators and physicians from around Canada.

Education / Training: 
University of Leicester, England B.Sc. (Hons) Biological Sciences 1985-1988
University of Oxford, England PhD Linkage analysis of atopy 1990-1993

Recent Publications: 
He J-Q, Burkett K, Connett JE, Anthonisen NR, Paré PD, Sandford AJ. Interferon gamma polymorphisms and their interaction with smoking are associated with lung function. Hum. Genet. 2006;119:365-375.

McKone EF, Shao J, Frangolias DD, Keener CL, Shephard CA, Farin FM, Pare PD, Sandford AJ, Aitken ML, Kavanagh TJ. Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease. Am. J. Respir. Crit. Care Med. 2006; 174:415-419.

Tremblay K, Lemire M, Provost V, Pastinen T, Renaud Y, Sandford AJ, Laviolette M, Hudson TJ, Laprise C. Association study between the CX3CR1 gene and asthma. Genes Immun. 2006;7:632-639.

Zhang X, Mahmudi-Azer S, Connett JE, Anthonisen NR, He J-Q, Paré PD, Sandford AJ. Association of Hck genetic polymorphisms with gene expression and COPD. Hum. Genet. 2007;120:681-690.

He J-Q, Shumansky K, Zhang X, Connett JE, Anthonisen NR, Sandford AJ. Polymorphisms of interleukin-10 and its receptor and lung function in COPD. Eur. Respir. J. 2007;29:1120-1126.

Dorfman R, Sandford A, Taylor C, Huang B, Frangolias D, Wang Y, Sang R, Pereira L, Sun L, Berthiaume Y, Tsui L-C, Paré PD, Durie P, Corey M, Zielenski J. Complex two-gene modulation of lung disease severity in children with cystic fibrosis. J. Clin. Invest. 2008 118:1040-1049.